Lab Notes: Biotechniques Archives - Laboratory Notes https://www.laboratorynotes.com/category/lab-notes-biotechniques/ Fri, 10 Oct 2025 17:19:51 +0000 en hourly 1 https://wordpress.org/?v=6.9 TensorFlow https://www.laboratorynotes.com/tensorflow/ https://www.laboratorynotes.com/tensorflow/#respond Fri, 10 Oct 2025 17:19:50 +0000 https://www.laboratorynotes.com/?p=26737 TensorFlow is an open-source software library developed by the Google Brain Team for numerical computation and large-scale machine learning. It...

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]]> https://www.laboratorynotes.com/tensorflow/feed/ 0 Keras https://www.laboratorynotes.com/keras/ https://www.laboratorynotes.com/keras/#respond Fri, 10 Oct 2025 17:17:17 +0000 https://www.laboratorynotes.com/?p=26735 Keras is an open-source, high-level neural network library designed to simplify the creation, training, and deployment of deep learning models....

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]]> https://www.laboratorynotes.com/keras/feed/ 0 PyTorch https://www.laboratorynotes.com/pytorch/ https://www.laboratorynotes.com/pytorch/#respond Fri, 10 Oct 2025 17:14:02 +0000 https://www.laboratorynotes.com/?p=26733 PyTorch is an open-source deep learning framework developed by Facebook’s AI Research Lab (FAIR) and officially released in 2016. It...

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]]> https://www.laboratorynotes.com/pytorch/feed/ 0 DNA Microarray https://www.laboratorynotes.com/dna-microarray/ https://www.laboratorynotes.com/dna-microarray/#respond Mon, 06 Oct 2025 23:45:41 +0000 https://www.laboratorynotes.com/?p=26728 A DNA microarray is a powerful molecular biology tool used to measure the expression levels of thousands of genes simultaneously...

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]]> https://www.laboratorynotes.com/dna-microarray/feed/ 0 Mechanism of Chain Termination in Sanger Sequencing https://www.laboratorynotes.com/mechanism-of-chain-termination-in-sanger-sequencing/ https://www.laboratorynotes.com/mechanism-of-chain-termination-in-sanger-sequencing/#respond Fri, 03 Oct 2025 10:19:44 +0000 https://www.laboratorynotes.com/?p=26701 In Sanger sequencing, a mixture of normal deoxyribonucleotides (dNTPs) and modified dideoxyribonucleotides (ddNTPs) is used to control DNA chain elongation. ...

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]]> https://www.laboratorynotes.com/mechanism-of-chain-termination-in-sanger-sequencing/feed/ 0 Sanger Sequencing: Historical Foundations to Modern Refinements https://www.laboratorynotes.com/sanger-sequencing-historical-foundations-to-modern-refinements/ https://www.laboratorynotes.com/sanger-sequencing-historical-foundations-to-modern-refinements/#respond Thu, 02 Oct 2025 21:09:50 +0000 https://www.laboratorynotes.com/?p=26685 Sanger Sequencing, also known as the chain-termination method, stands as one of the most significant breakthroughs in molecular biology. Developed...

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]]> https://www.laboratorynotes.com/sanger-sequencing-historical-foundations-to-modern-refinements/feed/ 0 Sanger Sequencing Vs Next-Generation Sequencing https://www.laboratorynotes.com/sanger-sequencing-vs-next-generation-sequencing/ https://www.laboratorynotes.com/sanger-sequencing-vs-next-generation-sequencing/#respond Mon, 29 Sep 2025 12:52:01 +0000 https://www.laboratorynotes.com/?p=26639 Criteria Sanger Sequencing Next-Generation Sequencing (NGS) Remarks Definition A first-generation DNA sequencing method based on selective incorporation of chain-terminating dideoxynucleotides...

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]]> https://www.laboratorynotes.com/sanger-sequencing-vs-next-generation-sequencing/feed/ 0 High-Throughput Genomic Sequencing Technology https://www.laboratorynotes.com/high-throughput-genomic-sequencing-technology/ https://www.laboratorynotes.com/high-throughput-genomic-sequencing-technology/#comments Mon, 29 Sep 2025 06:54:30 +0000 https://www.laboratorynotes.com/?p=26634 High-throughput genomic sequencing technologies, often referred to as next-generation sequencing (NGS), represent a transformative advancement in molecular biology and medicine,...

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]]> https://www.laboratorynotes.com/high-throughput-genomic-sequencing-technology/feed/ 1 Sequencing https://www.laboratorynotes.com/sequencing/ https://www.laboratorynotes.com/sequencing/#respond Sat, 27 Sep 2025 19:43:12 +0000 https://www.laboratorynotes.com/?p=26562 Sequencing refers to the experimental process of determining the precise order of the building blocks that make up a biological...

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]]> https://www.laboratorynotes.com/sequencing/feed/ 0 Common Substrates of Horseradish Peroxidase https://www.laboratorynotes.com/common-substrates-of-horseradish-peroxidase/ https://www.laboratorynotes.com/common-substrates-of-horseradish-peroxidase/#respond Mon, 22 Sep 2025 13:25:40 +0000 https://www.laboratorynotes.com/?p=26097 Horseradish peroxidase (HRP) is widely used in immunoassays and histological techniques because of its ability to catalyze the oxidation of...

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]]> https://www.laboratorynotes.com/common-substrates-of-horseradish-peroxidase/feed/ 0 Immunohistochemistry https://www.laboratorynotes.com/immunohistochemistry/ https://www.laboratorynotes.com/immunohistochemistry/#respond Mon, 22 Sep 2025 08:41:33 +0000 https://www.laboratorynotes.com/?p=25838 Immunohistochemistry (IHC) is a widely used laboratory technique that combines histology, immunology, and chemistry to detect and visualize the presence...

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]]> https://www.laboratorynotes.com/immunohistochemistry/feed/ 0 Antigen Retrieval https://www.laboratorynotes.com/antigen-retrieval/ https://www.laboratorynotes.com/antigen-retrieval/#respond Mon, 22 Sep 2025 07:33:54 +0000 https://www.laboratorynotes.com/?p=25836 Antigen retrieval is a crucial laboratory technique used in immunohistochemistry (IHC) and related staining methods to unmask antigenic sites (epitopes)...

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]]> https://www.laboratorynotes.com/antigen-retrieval/feed/ 0 Electron Microscopy https://www.laboratorynotes.com/electron-microscopy/ https://www.laboratorynotes.com/electron-microscopy/#respond Sat, 20 Sep 2025 19:08:20 +0000 https://www.laboratorynotes.com/?p=25823 Electron microscopy (EM) is a powerful imaging technique that uses a beam of electrons instead of visible light to visualize...

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]]> https://www.laboratorynotes.com/electron-microscopy/feed/ 0 Correlative NanoSIMS https://www.laboratorynotes.com/correlative-nanosims/ https://www.laboratorynotes.com/correlative-nanosims/#respond Sat, 20 Sep 2025 18:58:14 +0000 https://www.laboratorynotes.com/?p=25821 Correlative NanoSIMS is an advanced analytical approach that integrates nanoscale secondary ion mass spectrometry (NanoSIMS) with complementary imaging and analytical...

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]]> https://www.laboratorynotes.com/correlative-nanosims/feed/ 0 Nanoscale Secondary Ion Mass Spectrometry (NanoSIMS) https://www.laboratorynotes.com/nanoscale-secondary-ion-mass-spectrometry-nanosims/ https://www.laboratorynotes.com/nanoscale-secondary-ion-mass-spectrometry-nanosims/#respond Sat, 20 Sep 2025 18:16:05 +0000 https://www.laboratorynotes.com/?p=25809 Nanoscale Secondary Ion Mass Spectrometry (NanoSIMS) is an advanced surface analysis technique that provides high-resolution chemical and isotopic imaging at...

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]]> https://www.laboratorynotes.com/nanoscale-secondary-ion-mass-spectrometry-nanosims/feed/ 0 Time-of-Flight Secondary Ion Mass Spectrometry (TOF-SIMS) https://www.laboratorynotes.com/time-of-flight-secondary-ion-mass-spectrometry-tof-sims/ https://www.laboratorynotes.com/time-of-flight-secondary-ion-mass-spectrometry-tof-sims/#respond Sat, 20 Sep 2025 18:10:10 +0000 https://www.laboratorynotes.com/?p=25807 Time-of-Flight Secondary Ion Mass Spectrometry (TOF-SIMS) is a highly sensitive surface analysis technique that provides detailed chemical and molecular information...

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]]> https://www.laboratorynotes.com/time-of-flight-secondary-ion-mass-spectrometry-tof-sims/feed/ 0 ATP Assay https://www.laboratorynotes.com/atp-assay/ https://www.laboratorynotes.com/atp-assay/#respond Fri, 19 Sep 2025 21:20:32 +0000 https://www.laboratorynotes.com/?p=25799 An ATP assay is a biochemical method used to measure the amount of adenosine triphosphate (ATP) in biological samples.  ATP...

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]]> https://www.laboratorynotes.com/atp-assay/feed/ 0 Fluorophore https://www.laboratorynotes.com/fluorophore/ https://www.laboratorynotes.com/fluorophore/#respond Thu, 18 Sep 2025 22:49:58 +0000 https://www.laboratorynotes.com/?p=25779 A fluorophore is a fluorescent chemical compound that can absorb light at a specific wavelength and subsequently emit light at...

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]]> https://www.laboratorynotes.com/fluorophore/feed/ 0 4Pi microscope https://www.laboratorynotes.com/4pi-microscope/ https://www.laboratorynotes.com/4pi-microscope/#respond Thu, 18 Sep 2025 22:46:59 +0000 https://www.laboratorynotes.com/?p=25777 The 4Pi microscope is an advanced fluorescence microscopy technique designed to dramatically improve axial (z-axis) resolution beyond the diffraction limit...

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]]> https://www.laboratorynotes.com/4pi-microscope/feed/ 0 Abbe Diffraction Limit https://www.laboratorynotes.com/abbe-diffraction-limit/ https://www.laboratorynotes.com/abbe-diffraction-limit/#respond Thu, 18 Sep 2025 22:00:24 +0000 https://www.laboratorynotes.com/?p=25759 The Abbe diffraction limit is a fundamental concept in optical microscopy that describes the smallest resolvable feature size achievable with...

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