Lab Notes: Microscopy Archives - Laboratory Notes https://www.laboratorynotes.com/category/lab-notes-biotechniques/lab-notes-microscopy/ Mon, 22 Sep 2025 10:07:07 +0000 en hourly 1 https://wordpress.org/?v=6.9 Immunohistochemistry https://www.laboratorynotes.com/immunohistochemistry/ https://www.laboratorynotes.com/immunohistochemistry/#respond Mon, 22 Sep 2025 08:41:33 +0000 https://www.laboratorynotes.com/?p=25838 Immunohistochemistry (IHC) is a widely used laboratory technique that combines histology, immunology, and chemistry to detect and visualize the presence...

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]]> https://www.laboratorynotes.com/immunohistochemistry/feed/ 0 Electron Microscopy https://www.laboratorynotes.com/electron-microscopy/ https://www.laboratorynotes.com/electron-microscopy/#respond Sat, 20 Sep 2025 19:08:20 +0000 https://www.laboratorynotes.com/?p=25823 Electron microscopy (EM) is a powerful imaging technique that uses a beam of electrons instead of visible light to visualize...

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]]> https://www.laboratorynotes.com/electron-microscopy/feed/ 0 Fluorophore https://www.laboratorynotes.com/fluorophore/ https://www.laboratorynotes.com/fluorophore/#respond Thu, 18 Sep 2025 22:49:58 +0000 https://www.laboratorynotes.com/?p=25779 A fluorophore is a fluorescent chemical compound that can absorb light at a specific wavelength and subsequently emit light at...

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]]> https://www.laboratorynotes.com/fluorophore/feed/ 0 4Pi microscope https://www.laboratorynotes.com/4pi-microscope/ https://www.laboratorynotes.com/4pi-microscope/#respond Thu, 18 Sep 2025 22:46:59 +0000 https://www.laboratorynotes.com/?p=25777 The 4Pi microscope is an advanced fluorescence microscopy technique designed to dramatically improve axial (z-axis) resolution beyond the diffraction limit...

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]]> https://www.laboratorynotes.com/4pi-microscope/feed/ 0 Abbe Diffraction Limit https://www.laboratorynotes.com/abbe-diffraction-limit/ https://www.laboratorynotes.com/abbe-diffraction-limit/#respond Thu, 18 Sep 2025 22:00:24 +0000 https://www.laboratorynotes.com/?p=25759 The Abbe diffraction limit is a fundamental concept in optical microscopy that describes the smallest resolvable feature size achievable with...

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]]> https://www.laboratorynotes.com/abbe-diffraction-limit/feed/ 0 Diffraction-Limited System https://www.laboratorynotes.com/diffraction-limited-system/ https://www.laboratorynotes.com/diffraction-limited-system/#respond Thu, 18 Sep 2025 21:29:37 +0000 https://www.laboratorynotes.com/?p=25756 A diffraction-limited system refers to an optical system whose resolution is restricted solely by the fundamental effects of diffraction, rather...

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]]> https://www.laboratorynotes.com/diffraction-limited-system/feed/ 0 STED Microscopy https://www.laboratorynotes.com/sted-microscopy/ https://www.laboratorynotes.com/sted-microscopy/#respond Thu, 18 Sep 2025 20:53:39 +0000 https://www.laboratorynotes.com/?p=25754 Stimulated Emission Depletion (STED) microscopy is a super-resolution fluorescence imaging technique that overcomes the diffraction limit of conventional light microscopy. ...

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]]> https://www.laboratorynotes.com/sted-microscopy/feed/ 0 Incucyte https://www.laboratorynotes.com/incucyte/ https://www.laboratorynotes.com/incucyte/#respond Sat, 23 Aug 2025 06:28:22 +0000 https://www.laboratorynotes.com/?p=24047 The Incucyte is a live-cell imaging and analysis system designed to enable continuous, non-invasive monitoring of cell cultures within a...

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]]> https://www.laboratorynotes.com/incucyte/feed/ 0 Holographic Microscopy https://www.laboratorynotes.com/holographic-microscopy/ https://www.laboratorynotes.com/holographic-microscopy/#respond Sat, 16 Aug 2025 17:40:26 +0000 https://www.laboratorynotes.com/?p=23823 Holographic microscopy is an advanced imaging technique that combines the principles of holography with microscopy to obtain high-resolution, three-dimensional images...

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]]> https://www.laboratorynotes.com/holographic-microscopy/feed/ 0 Stochastic Optical Reconstruction Microscopy https://www.laboratorynotes.com/stochastic-optical-reconstruction-microscopy/ https://www.laboratorynotes.com/stochastic-optical-reconstruction-microscopy/#respond Sun, 10 Aug 2025 21:05:02 +0000 https://www.laboratorynotes.com/?p=23294 Stochastic Optical Reconstruction Microscopy (STORM) is a single-molecule super-resolution imaging technique that enables visualization of biological structures at resolutions down...

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]]> https://www.laboratorynotes.com/stochastic-optical-reconstruction-microscopy/feed/ 0 Photoactivated Localization Microscopy (PALM) https://www.laboratorynotes.com/photoactivated-localization-microscopy-palm/ https://www.laboratorynotes.com/photoactivated-localization-microscopy-palm/#respond Sun, 10 Aug 2025 20:21:00 +0000 https://www.laboratorynotes.com/?p=23291 Photoactivated Localization Microscopy (PALM) is a single-molecule super-resolution imaging technique that overcomes the diffraction limit of light microscopy, allowing researchers...

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]]> https://www.laboratorynotes.com/photoactivated-localization-microscopy-palm/feed/ 0 MINFLUX https://www.laboratorynotes.com/minflux/ https://www.laboratorynotes.com/minflux/#respond Sun, 10 Aug 2025 16:03:40 +0000 https://www.laboratorynotes.com/?p=23276 MINFLUX (Minimal Photon Fluxes) is an advanced single-molecule localization microscopy technique that achieves nanometer-scale resolution with unprecedented efficiency in photon...

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]]> https://www.laboratorynotes.com/minflux/feed/ 0 Scanning Tunneling Microscope https://www.laboratorynotes.com/scanning-tunneling-microscope/ https://www.laboratorynotes.com/scanning-tunneling-microscope/#respond Wed, 06 Aug 2025 08:33:07 +0000 https://www.laboratorynotes.com/?p=22959 The Scanning Tunneling Microscope (STM) is a powerful analytical instrument that enables scientists to image and manipulate surfaces at the...

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]]> https://www.laboratorynotes.com/scanning-tunneling-microscope/feed/ 0 Tissue Clearing https://www.laboratorynotes.com/tissue-clearing/ https://www.laboratorynotes.com/tissue-clearing/#respond Sun, 11 May 2025 06:55:14 +0000 https://www.laboratorynotes.com/?p=19006 Tissue clearing is a revolutionary technique in biological imaging that renders opaque tissues transparent, allowing researchers to visualize deep structures...

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]]> https://www.laboratorynotes.com/tissue-clearing/feed/ 0 CLARITY (Clear Lipid-exchanged Acrylamide-hybridized Rigid Imaging/Immunostaining/In situ hybridization-compatible Tissue-hYdrogel) https://www.laboratorynotes.com/clarity-clear-lipid-exchanged-acrylamide-hybridized-rigid-imaging-immunostaining-in-situ-hybridization-compatible-tissue-hydrogel/ https://www.laboratorynotes.com/clarity-clear-lipid-exchanged-acrylamide-hybridized-rigid-imaging-immunostaining-in-situ-hybridization-compatible-tissue-hydrogel/#respond Sun, 11 May 2025 06:52:21 +0000 https://www.laboratorynotes.com/?p=19004 CLARITY (Clear Lipid-exchanged Acrylamide-hybridized Rigid Imaging/Immunostaining/In situ hybridization-compatible Tissue-hYdrogel) is a groundbreaking tissue clearing method that transforms intact biological tissues...

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]]> https://www.laboratorynotes.com/clarity-clear-lipid-exchanged-acrylamide-hybridized-rigid-imaging-immunostaining-in-situ-hybridization-compatible-tissue-hydrogel/feed/ 0 CUBIC (Clear, Unobstructed Brain/Body Imaging Cocktails and Computational analysis) https://www.laboratorynotes.com/cubic-clear-unobstructed-brain-body-imaging-cocktails-and-computational-analysis/ https://www.laboratorynotes.com/cubic-clear-unobstructed-brain-body-imaging-cocktails-and-computational-analysis/#respond Sun, 11 May 2025 06:49:09 +0000 https://www.laboratorynotes.com/?p=19002 CUBIC (Clear, Unobstructed Brain/Body Imaging Cocktails and Computational analysis) is a comprehensive tissue clearing method that uses simple, hydrophilic chemicals...

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]]> https://www.laboratorynotes.com/cubic-clear-unobstructed-brain-body-imaging-cocktails-and-computational-analysis/feed/ 0 DISCO (Tissue Clearing Method) https://www.laboratorynotes.com/disco-tissue-clearing-method/ https://www.laboratorynotes.com/disco-tissue-clearing-method/#respond Sun, 11 May 2025 06:33:46 +0000 https://www.laboratorynotes.com/?p=19000 DISCO (3DISCO, iDISCO, uDISCO) represents a family of organic solvent-based tissue clearing methods that have revolutionized the way researchers visualize...

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]]> https://www.laboratorynotes.com/disco-tissue-clearing-method/feed/ 0 SCALE (Sorbitol/Calf serum/Alpha-lipoic acid/Ellipsenone) https://www.laboratorynotes.com/scale-sorbitol-calf-serum-alpha-lipoic-acid-ellipsenone/ https://www.laboratorynotes.com/scale-sorbitol-calf-serum-alpha-lipoic-acid-ellipsenone/#respond Sun, 11 May 2025 06:30:00 +0000 https://www.laboratorynotes.com/?p=18998 SCALE (Sorbitol/Calf serum/Alpha-lipoic acid/Ellipsenone) is a hydrophilic tissue clearing method that achieves transparency through hyperhydration while preserving fluorescent proteins and...

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]]> https://www.laboratorynotes.com/scale-sorbitol-calf-serum-alpha-lipoic-acid-ellipsenone/feed/ 0 SeeDB (See Deep Brain) https://www.laboratorynotes.com/seedb-see-deep-brain/ https://www.laboratorynotes.com/seedb-see-deep-brain/#respond Sun, 11 May 2025 06:15:46 +0000 https://www.laboratorynotes.com/?p=18996 SeeDB (See Deep Brain) is an optical clearing method that utilizes simple sugar solutions to render biological tissues transparent while...

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]]> https://www.laboratorynotes.com/seedb-see-deep-brain/feed/ 0 Serial Two-Photon Tomography https://www.laboratorynotes.com/serial-two-photon-tomography/ https://www.laboratorynotes.com/serial-two-photon-tomography/#respond Sat, 10 May 2025 23:38:14 +0000 https://www.laboratorynotes.com/?p=18992 Serial Two-Photon Tomography (STPT) is an advanced imaging technique that combines the high-resolution, depthpenetra-ting capabilities of two-photon microscopy with automated...

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