Lab Notes: Pharmaceutical Industry Archives - Laboratory Notes

Systems Biology and Pathway Analysis

admin — Thu, 24 Sep 2026 11:09:11 +0000

Systems biology integrates genes, proteins, metabolites, pathways and molecular networks to understand how biological systems function and respond to perturbations. Learn how pathway analysis and multi-omics reveal complex biological mechanisms.

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Drug-Target Interactions and Polypharmacology

admin — Thu, 24 Sep 2026 10:55:48 +0000

Drug-target interactions describe how drugs bind and modulate biological targets, while polypharmacology examines how a single drug can affect multiple proteins and pathways. Explore molecular binding, target selectivity, off-target effects and computational approaches to drug discovery.

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Binding Free-Energy Calculations: Quantifying Protein-Ligand Binding Affinity

admin — Thu, 24 Sep 2026 10:33:10 +0000

Binding free-energy calculations use thermodynamic and molecular simulation methods to estimate how strongly ligands bind proteins. Learn about MM-GBSA, MM-PBSA, FEP, thermodynamic integration, sampling, validation and applications in drug discovery.

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Molecular Dynamics Simulation

admin — Thu, 24 Sep 2026 10:17:24 +0000

Molecular dynamics simulations use computational models to study how proteins, ligands, water and other molecules move over time. Learn how molecular dynamics reveals protein flexibility, binding-site dynamics, molecular interactions, allostery and drug-binding behavior.

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Structure-Based Drug Design

admin — Thu, 24 Sep 2026 10:08:59 +0000

Structure-based drug design uses three-dimensional protein structures to guide the discovery and optimization of drug candidates. Learn how binding sites, molecular interactions, docking, structural biology and medicinal chemistry work together in modern drug discovery.

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Virtual Screening for Finding Potential Drug Candidates

admin — Thu, 24 Sep 2026 09:52:37 +0000

Virtual screening uses computational methods to search large chemical libraries and identify compounds that may interact with biological targets. Learn how docking, pharmacophore screening, chemical similarity, QSAR and machine learning support drug discovery.

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RNA-Based Therapeutics

admin — Sun, 13 Sep 2026 22:39:09 +0000

RNA-based therapeutics use molecules such as mRNA, siRNA, and antisense oligonucleotides to influence gene expression, protein production, RNA processing, and cellular function. Explore RNA therapy, delivery systems, RNA interference, gene regulation, and applications in genetic medicine.

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Proteasome Inhibitor

admin — Sat, 08 Aug 2026 07:44:15 +0000

Proteasome inhibitors block proteasomal degradation of ubiquitinated proteins, disrupting cellular regulation and inducing apoptosis. This article explains their mechanisms, therapeutic uses, and biological significance.

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