Antiviral defence Archives - Laboratory Notes https://www.laboratorynotes.com/tag/antiviral-defence/ Wed, 26 Aug 2026 07:57:24 +0000 en hourly 1 https://wordpress.org/?v=7.1.2 TRIM Family https://www.laboratorynotes.com/trim-family/ https://www.laboratorynotes.com/trim-family/#respond Sun, 23 Aug 2026 20:20:49 +0000 https://www.laboratorynotes.com/?p=29825 The TRIM family is a large group of single‑chain RING finger ubiquitin ligases that regulate innate immunity, antiviral defence, autophagy, transcription and protein quality control. Defined by their tripartite motif—RING, B‑box and coiled‑coil domains—TRIM proteins use diverse C‑terminal regions to achieve precise substrate specificity. Their roles in immunity, development and cancer make them key regulators of cellular homeostasis.

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]]> https://www.laboratorynotes.com/trim-family/feed/ 0 RNF115 (RING Finger Protein 115) https://www.laboratorynotes.com/rnf115-ring-finger-protein-115/ https://www.laboratorynotes.com/rnf115-ring-finger-protein-115/#respond Fri, 21 Aug 2026 09:51:17 +0000 https://www.laboratorynotes.com/?p=29796 RNF115 (BCA2) is a dual RING/U‑box E3 ubiquitin ligase that regulates membrane trafficking, innate immunity and antiviral defence. By ubiquitinating BST‑2/Tetherin, Rab7‑associated endosomal proteins and EGFR, RNF115 influences receptor turnover, immune signalling and cancer progression, making it a key regulator of cellular homeostasis.

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