Antiviral immunity Archives - Laboratory Notes https://www.laboratorynotes.com/tag/antiviral-immunity/ Sun, 23 Aug 2026 20:33:41 +0000 en hourly 1 https://wordpress.org/?v=7.1 TRIM21 https://www.laboratorynotes.com/trim21/ https://www.laboratorynotes.com/trim21/#respond Sun, 23 Aug 2026 20:33:41 +0000 https://www.laboratorynotes.com/?p=29829 TRIM21 is a unique intracellular antibody receptor and RING finger ubiquitin ligase that neutralises antibody‑coated viruses inside the cytosol. Through its PRY/SPRY domain and tripartite motif, TRIM21 triggers rapid ubiquitin‑mediated degradation and activates antiviral signalling pathways. Its roles in immunity, autoimmunity and biotechnology make TRIM21 a key regulator of intracellular defence.

The post TRIM21 appeared first on Laboratory Notes.

]]> https://www.laboratorynotes.com/trim21/feed/ 0 TRIM25 https://www.laboratorynotes.com/trim25/ https://www.laboratorynotes.com/trim25/#respond Sun, 23 Aug 2026 20:28:33 +0000 https://www.laboratorynotes.com/?p=29827 TRIM25 is a RING finger ubiquitin ligase that activates the antiviral sensor RIG‑I through K63‑linked ubiquitination. Its tripartite motif and PRY/SPRY domain enable precise regulation of innate immune signalling, interferon production and viral restriction. TRIM25 is targeted by multiple viruses, highlighting its importance as a frontline antiviral factor.

The post TRIM25 appeared first on Laboratory Notes.

]]> https://www.laboratorynotes.com/trim25/feed/ 0