Apoptosis Archives - Laboratory Notes https://www.laboratorynotes.com/tag/apoptosis/ Mon, 24 Aug 2026 08:41:30 +0000 en hourly 1 https://wordpress.org/?v=7.1 Survivin https://www.laboratorynotes.com/survivin/ https://www.laboratorynotes.com/survivin/#respond Mon, 24 Aug 2026 08:41:30 +0000 https://www.laboratorynotes.com/?p=29858 Survivin (BIRC5) is a tumour‑specific IAP that integrates apoptosis suppression with essential mitotic functions. As part of the chromosomal passenger complex, Survivin ensures proper chromosome segregation while stabilising anti‑apoptotic pathways, making it a central driver of tumour progression and therapy resistance.

The post Survivin appeared first on Laboratory Notes.

]]> https://www.laboratorynotes.com/survivin/feed/ 0 Livin (ML‑IAP) https://www.laboratorynotes.com/livin-ml-iap/ https://www.laboratorynotes.com/livin-ml-iap/#respond Mon, 24 Aug 2026 08:27:12 +0000 https://www.laboratorynotes.com/?p=29853 Livin (ML‑IAP) is a tumour‑specific inhibitor of apoptosis that blocks caspase activity and ubiquitinates pro‑apoptotic proteins. Its splice variants, Livin‑α and Livin‑β, differ in potency, and its unique ability to switch from anti‑apoptotic to pro‑apoptotic after cleavage makes Livin a key regulator of tumour survival and therapy resistance.

The post Livin (ML‑IAP) appeared first on Laboratory Notes.

]]> https://www.laboratorynotes.com/livin-ml-iap/feed/ 0 cIAP2 https://www.laboratorynotes.com/ciap2/ https://www.laboratorynotes.com/ciap2/#respond Mon, 24 Aug 2026 08:17:31 +0000 https://www.laboratorynotes.com/?p=29851 cIAP2 is a ubiquitin ligase that regulates TNF receptor signalling, non‑canonical NF‑κB activation and NOD2‑mediated immune responses. By controlling RIPK1, RIPK2 and NIK stability, cIAP2 determines whether cells activate survival pathways or transition into apoptosis, making it essential in inflammation and cancer biology.

The post cIAP2 appeared first on Laboratory Notes.

]]> https://www.laboratorynotes.com/ciap2/feed/ 0 cIAP1 https://www.laboratorynotes.com/ciap1/ https://www.laboratorynotes.com/ciap1/#respond Mon, 24 Aug 2026 08:12:48 +0000 https://www.laboratorynotes.com/?p=29849 cIAP1 is a ubiquitin ligase that regulates TNF receptor signalling and determines whether cells activate NF‑κB survival pathways or switch into apoptosis or necroptosis. By controlling RIPK1 ubiquitination and cooperating with TRAF2, cIAP1 plays essential roles in inflammation, immunity and cancer biology.

The post cIAP1 appeared first on Laboratory Notes.

]]> https://www.laboratorynotes.com/ciap1/feed/ 0