ATR signalling Archives - Laboratory Notes https://www.laboratorynotes.com/tag/atr-signalling/ Wed, 02 Sep 2026 08:05:51 +0000 en hourly 1 https://wordpress.org/?v=7.1.2 Replication Stress https://www.laboratorynotes.com/replication-stress/ https://www.laboratorynotes.com/replication-stress/#respond Fri, 28 Aug 2026 18:00:26 +0000 https://www.laboratorynotes.com/?p=30089 Replication stress occurs when DNA replication forks stall or collapse, generating genomic instability and driving tumour evolution. Through ATR–CHK1 signalling, fork protection and homologous recombination repair, cells stabilise damaged forks and prevent catastrophic chromosomal breakage.

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