Autoimmunity Archives - Laboratory Notes https://www.laboratorynotes.com/tag/autoimmunity/ Sun, 23 Aug 2026 20:02:09 +0000 en hourly 1 https://wordpress.org/?v=7.1 Cbl‑b https://www.laboratorynotes.com/cbl-b/ https://www.laboratorynotes.com/cbl-b/#respond Sun, 23 Aug 2026 20:02:09 +0000 https://www.laboratorynotes.com/?p=29820 Cbl‑b is a single‑chain RING finger ubiquitin ligase that acts as a master regulator of immune activation. By ubiquitinating key signalling molecules in T‑cells, B‑cells and NK cells, Cbl‑b maintains immune tolerance and prevents hyperactivation. Loss of Cbl‑b leads to autoimmunity and enhanced anti‑tumour immunity, making it a critical player in immune homeostasis and a promising target in cancer immunotherapy.

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