BubR1 Archives - Laboratory Notes https://www.laboratorynotes.com/tag/bubr1/ Wed, 19 Aug 2026 11:06:58 +0000 en hourly 1 https://wordpress.org/?v=7.0.3 Cdc20 https://www.laboratorynotes.com/cdc20/ https://www.laboratorynotes.com/cdc20/#respond Wed, 19 Aug 2026 11:02:18 +0000 https://www.laboratorynotes.com/?p=29687 Cdc20 is a key activator of the APC/C complex, initiating the metaphase‑to‑anaphase transition by promoting securin and Cyclin B degradation. Regulated by checkpoint proteins such as Mad2 and BubR1, Cdc20 safeguards chromosome segregation, while its dysregulation contributes to aneuploidy and cancer progression.

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