Cbl‑c. CBL family Archives - Laboratory Notes https://www.laboratorynotes.com/tag/cbl-c-cbl-family/ Sun, 23 Aug 2026 20:10:02 +0000 en hourly 1 https://wordpress.org/?v=7.1 Cbl‑c https://www.laboratorynotes.com/cbl-c/ https://www.laboratorynotes.com/cbl-c/#respond Sun, 23 Aug 2026 20:10:02 +0000 https://www.laboratorynotes.com/?p=29823 Cbl‑c is an epithelial‑specific RING finger ubiquitin ligase that regulates EGFR and other receptor tyrosine kinases through targeted ubiquitination. With a streamlined domain architecture and restricted expression pattern, Cbl‑c maintains epithelial homeostasis and prevents excessive RTK signalling. Loss or mutation of Cbl‑c contributes to epithelial cancers, highlighting its importance in growth control and oncogenesis.

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