Cell signalling Archives - Laboratory Notes https://www.laboratorynotes.com/tag/cell-signalling/ Wed, 02 Sep 2026 08:09:27 +0000 en hourly 1 https://wordpress.org/?v=7.1.2 Cell Signalling Pathway https://www.laboratorynotes.com/cell-signalling-pathway/ https://www.laboratorynotes.com/cell-signalling-pathway/#comments Thu, 27 Aug 2026 14:57:53 +0000 https://www.laboratorynotes.com/?p=30024 Cell signalling pathways are the communication networks that allow cells to detect signals, activate molecular cascades, and coordinate essential functions. This article explains how signalling works, how pathways are activated, and why they are vital for cellular health and survival.

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]]> https://www.laboratorynotes.com/cell-signalling-pathway/feed/ 1 c‑Cbl https://www.laboratorynotes.com/c-cbl/ https://www.laboratorynotes.com/c-cbl/#respond Sun, 23 Aug 2026 19:07:22 +0000 https://www.laboratorynotes.com/?p=29816 c‑Cbl is a single‑chain RING finger ubiquitin ligase that regulates receptor tyrosine kinase signalling by binding phosphorylated RTKs and catalysing their ubiquitination. Through its TKB domain and RING domain, c‑Cbl controls EGFR turnover, immune signalling and cell growth. Mutations in c‑Cbl disrupt ubiquitination and contribute to myeloid malignancies, highlighting its importance in cellular homeostasis and disease.

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