ERAD Archives - Laboratory Notes

ATF6

admin — Sat, 29 Aug 2026 09:58:21 +0000

ATF6 is an ER stress‑responsive transcription factor that enhances protein‑folding capacity and strengthens ER‑associated degradation. After trafficking to the Golgi and undergoing regulated proteolysis, ATF6 activates genes that restore ER proteostasis during unfolded protein accumulation.

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Endoplasmic Reticulum Stress

admin — Sat, 29 Aug 2026 09:50:51 +0000

ER stress arises when misfolded proteins accumulate in the endoplasmic reticulum, overwhelming its folding capacity. Through IRE1, PERK and ATF6 signalling, the unfolded protein response restores proteostasis, reduces protein load and protects cells from stress‑induced damage.

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Endoplasmic Reticulum Associated Degradation

admin — Thu, 27 Aug 2026 00:18:51 +0000

ERAD is a central ER quality‑control pathway that recognises misfolded proteins, retrotranslocates them to the cytosol, ubiquitinates them and directs them to the proteasome. By preventing proteotoxic accumulation, ERAD preserves ER homeostasis and supports cellular proteostasis.

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Unfolded Protein Response

admin — Wed, 26 Aug 2026 23:29:46 +0000

The unfolded protein response (UPR) is a conserved ER stress pathway that detects misfolded proteins and restores proteostasis. Through IRE1, PERK and ATF6 signalling, cells expand folding capacity, reduce protein load and maintain homeostasis under conditions of ER stress.

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