ERAD Archives - Laboratory Notes https://www.laboratorynotes.com/tag/erad/ Thu, 27 Aug 2026 00:18:51 +0000 en hourly 1 https://wordpress.org/?v=7.1 Endoplasmic Reticulum Associated Degradation https://www.laboratorynotes.com/endoplasmic-reticulum-associated-degradation/ https://www.laboratorynotes.com/endoplasmic-reticulum-associated-degradation/#respond Thu, 27 Aug 2026 00:18:51 +0000 https://www.laboratorynotes.com/?p=30007 ERAD is a central ER quality‑control pathway that recognises misfolded proteins, retrotranslocates them to the cytosol, ubiquitinates them and directs them to the proteasome. By preventing proteotoxic accumulation, ERAD preserves ER homeostasis and supports cellular proteostasis.

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]]> https://www.laboratorynotes.com/endoplasmic-reticulum-associated-degradation/feed/ 0 Unfolded Protein Response https://www.laboratorynotes.com/unfolded-protein-response/ https://www.laboratorynotes.com/unfolded-protein-response/#respond Wed, 26 Aug 2026 23:29:46 +0000 https://www.laboratorynotes.com/?p=29995 The unfolded protein response (UPR) is a conserved ER stress pathway that detects misfolded proteins and restores proteostasis. Through IRE1, PERK and ATF6 signalling, cells expand folding capacity, reduce protein load and maintain homeostasis under conditions of ER stress.

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