IRE1 Archives - Laboratory Notes https://www.laboratorynotes.com/tag/ire1/ Wed, 02 Sep 2026 08:11:09 +0000 en hourly 1 https://wordpress.org/?v=7.1.2 Endoplasmic Reticulum Stress https://www.laboratorynotes.com/endoplasmic-reticulum-stress/ https://www.laboratorynotes.com/endoplasmic-reticulum-stress/#respond Sat, 29 Aug 2026 09:50:51 +0000 https://www.laboratorynotes.com/?p=29999 ER stress arises when misfolded proteins accumulate in the endoplasmic reticulum, overwhelming its folding capacity. Through IRE1, PERK and ATF6 signalling, the unfolded protein response restores proteostasis, reduces protein load and protects cells from stress‑induced damage.

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]]> https://www.laboratorynotes.com/endoplasmic-reticulum-stress/feed/ 0 IRE1 https://www.laboratorynotes.com/ire1/ https://www.laboratorynotes.com/ire1/#respond Thu, 27 Aug 2026 00:01:37 +0000 https://www.laboratorynotes.com/?p=30001 IRE1 is the most conserved ER stress sensor, activating XBP1 splicing and RIDD to restore proteostasis. Through its kinase and RNase activities, IRE1 detects misfolded proteins, initiates adaptive signalling and coordinates the unfolded protein response during ER stress.

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]]> https://www.laboratorynotes.com/ire1/feed/ 0 Unfolded Protein Response https://www.laboratorynotes.com/unfolded-protein-response/ https://www.laboratorynotes.com/unfolded-protein-response/#respond Wed, 26 Aug 2026 23:29:46 +0000 https://www.laboratorynotes.com/?p=29995 The unfolded protein response (UPR) is a conserved ER stress pathway that detects misfolded proteins and restores proteostasis. Through IRE1, PERK and ATF6 signalling, cells expand folding capacity, reduce protein load and maintain homeostasis under conditions of ER stress.

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