IRE1 Archives - Laboratory Notes https://www.laboratorynotes.com/tag/ire1/ Thu, 27 Aug 2026 00:01:37 +0000 en hourly 1 https://wordpress.org/?v=7.1 IRE1 https://www.laboratorynotes.com/ire1/ https://www.laboratorynotes.com/ire1/#respond Thu, 27 Aug 2026 00:01:37 +0000 https://www.laboratorynotes.com/?p=30001 IRE1 is the most conserved ER stress sensor, activating XBP1 splicing and RIDD to restore proteostasis. Through its kinase and RNase activities, IRE1 detects misfolded proteins, initiates adaptive signalling and coordinates the unfolded protein response during ER stress.

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]]> https://www.laboratorynotes.com/ire1/feed/ 0 Unfolded Protein Response https://www.laboratorynotes.com/unfolded-protein-response/ https://www.laboratorynotes.com/unfolded-protein-response/#respond Wed, 26 Aug 2026 23:29:46 +0000 https://www.laboratorynotes.com/?p=29995 The unfolded protein response (UPR) is a conserved ER stress pathway that detects misfolded proteins and restores proteostasis. Through IRE1, PERK and ATF6 signalling, cells expand folding capacity, reduce protein load and maintain homeostasis under conditions of ER stress.

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