Kinetochore Archives - Laboratory Notes https://www.laboratorynotes.com/tag/kinetochore/ Wed, 26 Aug 2026 07:49:02 +0000 en hourly 1 https://wordpress.org/?v=7.1.2 Aurora C https://www.laboratorynotes.com/aurora-c/ https://www.laboratorynotes.com/aurora-c/#respond Tue, 25 Aug 2026 23:24:06 +0000 https://www.laboratorynotes.com/?p=29881 Aurora C kinase is a germ‑cell‑enriched member of the Chromosomal Passenger Complex that safeguards meiotic chromosome segregation. By regulating kinetochore–microtubule interactions and cytokinesis, Aurora C ensures gamete quality and genomic stability. Its dysregulation contributes to infertility and tumour progression.

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]]> https://www.laboratorynotes.com/aurora-c/feed/ 0 Kinetochore https://www.laboratorynotes.com/kinetochore/ https://www.laboratorynotes.com/kinetochore/#respond Tue, 25 Aug 2026 23:04:59 +0000 https://www.laboratorynotes.com/?p=29876 The kinetochore is a dynamic protein complex assembled on centromeric chromatin that binds spindle microtubules, generates tension and ensures accurate chromosome segregation. Through coordinated interactions with Aurora B kinase and spindle checkpoint signalling, the kinetochore maintains mitotic fidelity and prevents aneuploidy.

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]]> https://www.laboratorynotes.com/kinetochore/feed/ 0 Spindle Assembly Checkpoint https://www.laboratorynotes.com/spindle-assembly-checkpoint/ https://www.laboratorynotes.com/spindle-assembly-checkpoint/#respond Tue, 25 Aug 2026 22:44:59 +0000 https://www.laboratorynotes.com/?p=29873 The spindle assembly checkpoint (SAC) is a mitotic surveillance system that prevents premature anaphase onset by monitoring kinetochore–microtubule attachment and tension. Through coordinated action with Aurora B kinase and the Chromosomal Passenger Complex, the SAC ensures accurate chromosome segregation and protects cells from aneuploidy.

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]]> https://www.laboratorynotes.com/spindle-assembly-checkpoint/feed/ 0 Mitotic Error Correction https://www.laboratorynotes.com/mitotic-error-correction/ https://www.laboratorynotes.com/mitotic-error-correction/#respond Tue, 25 Aug 2026 22:00:20 +0000 https://www.laboratorynotes.com/?p=29869 Mitotic error correction is a tension‑sensing mechanism that detects and destabilises incorrect kinetochore–microtubule attachments. Driven by Aurora B kinase and the Chromosomal Passenger Complex, this process ensures accurate chromosome segregation and prevents aneuploidy, making it essential for genomic stability.

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