MAVS pathway Archives - Laboratory Notes https://www.laboratorynotes.com/tag/mavs-pathway/ Tue, 25 Aug 2026 07:19:37 +0000 en hourly 1 https://wordpress.org/?v=7.1 RIG‑I https://www.laboratorynotes.com/rig-i/ https://www.laboratorynotes.com/rig-i/#respond Tue, 25 Aug 2026 07:19:37 +0000 https://www.laboratorynotes.com/?p=29833 RIG‑I is a cytosolic pattern‑recognition receptor that detects viral RNA and activates innate immunity. Its CARD domains become exposed and ubiquitinated by TRIM25, enabling RIG‑I to bind MAVS and trigger interferon production. Through this pathway, RIG‑I converts viral RNA detection into a strong antiviral response.

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]]> https://www.laboratorynotes.com/rig-i/feed/ 0 MDA5 https://www.laboratorynotes.com/mda5/ https://www.laboratorynotes.com/mda5/#respond Tue, 25 Aug 2026 06:55:32 +0000 https://www.laboratorynotes.com/?p=29835 MDA5 is a cytosolic receptor that detects long viral double‑stranded RNA and activates MAVS‑dependent interferon signalling. Its ATP‑driven filament formation enables precise recognition of replicating RNA viruses, while LGP2 stabilises MDA5 filaments to ensure accurate antiviral responses.

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