Mitophagy Archives - Laboratory Notes https://www.laboratorynotes.com/tag/mitophagy/ Fri, 21 Aug 2026 09:25:22 +0000 en hourly 1 https://wordpress.org/?v=7.1 RBR Ubiquitin Ligase https://www.laboratorynotes.com/rbr-ubiquitin-ligase/ https://www.laboratorynotes.com/rbr-ubiquitin-ligase/#comments Fri, 21 Aug 2026 09:25:22 +0000 https://www.laboratorynotes.com/?p=29789 RBR ubiquitin ligases are hybrid E3 enzymes that combine RING‑type E2 binding with HECT‑like catalytic ubiquitin transfer. Through key members such as Parkin, HHARI and HOIP, the RBR family regulates mitophagy, protein‑quality control and M1‑linked ubiquitination in immune signalling, making them central to cellular stress responses and disease mechanisms.

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