PERK Archives - Laboratory Notes https://www.laboratorynotes.com/tag/perk/ Thu, 27 Aug 2026 00:05:54 +0000 en hourly 1 https://wordpress.org/?v=7.1 PERK https://www.laboratorynotes.com/perk/ https://www.laboratorynotes.com/perk/#respond Thu, 27 Aug 2026 00:05:54 +0000 https://www.laboratorynotes.com/?p=30003 PERK is a central ER stress sensor that phosphorylates eIF2α, reduces protein synthesis and activates ATF4‑dependent transcription. Through adaptive and apoptotic signalling, PERK coordinates unfolded protein response pathways that restore proteostasis or eliminate irreparably damaged cells.

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]]> https://www.laboratorynotes.com/perk/feed/ 0 Unfolded Protein Response https://www.laboratorynotes.com/unfolded-protein-response/ https://www.laboratorynotes.com/unfolded-protein-response/#respond Wed, 26 Aug 2026 23:29:46 +0000 https://www.laboratorynotes.com/?p=29995 The unfolded protein response (UPR) is a conserved ER stress pathway that detects misfolded proteins and restores proteostasis. Through IRE1, PERK and ATF6 signalling, cells expand folding capacity, reduce protein load and maintain homeostasis under conditions of ER stress.

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