Replication stress Archives - Laboratory Notes https://www.laboratorynotes.com/tag/replication-stress/ Wed, 09 Sep 2026 09:58:22 +0000 en hourly 1 https://wordpress.org/?v=7.1.2 DNA Damage Response https://www.laboratorynotes.com/dna-damage-response/ https://www.laboratorynotes.com/dna-damage-response/#respond Sat, 29 Aug 2026 09:41:29 +0000 https://www.laboratorynotes.com/?p=30051 The DNA damage response is a cellular defense system that detects DNA damage, coordinates repair, regulates cell-cycle checkpoints, and protects the stability of the genome.

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]]> https://www.laboratorynotes.com/dna-damage-response/feed/ 0 ATR https://www.laboratorynotes.com/atr/ https://www.laboratorynotes.com/atr/#respond Sat, 29 Aug 2026 09:13:25 +0000 https://www.laboratorynotes.com/?p=30063 ATR is a key protein kinase that protects cells from replication stress and DNA damage. Explore how ATR detects single-stranded DNA, stabilizes replication forks, activates CHK1, and maintains genome stability.

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]]> https://www.laboratorynotes.com/atr/feed/ 0 Replication Stress https://www.laboratorynotes.com/replication-stress/ https://www.laboratorynotes.com/replication-stress/#respond Fri, 28 Aug 2026 18:00:26 +0000 https://www.laboratorynotes.com/?p=30089 Replication stress occurs when DNA replication forks stall or collapse, generating genomic instability and driving tumour evolution. Through ATR–CHK1 signalling, fork protection and homologous recombination repair, cells stabilise damaged forks and prevent catastrophic chromosomal breakage.

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]]> https://www.laboratorynotes.com/replication-stress/feed/ 0 BRCA1 https://www.laboratorynotes.com/brca1/ https://www.laboratorynotes.com/brca1/#respond Fri, 28 Aug 2026 17:53:46 +0000 https://www.laboratorynotes.com/?p=30087 BRCA1 is a central tumour‑suppressor protein that regulates homologous recombination, DNA end resection and checkpoint signalling. By coordinating high‑fidelity DNA repair and protecting replication forks, BRCA1 maintains genome stability and prevents oncogenic transformation.

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]]> https://www.laboratorynotes.com/brca1/feed/ 0 DNA Damage Response Pathways https://www.laboratorynotes.com/dna-damage-response-pathways/ https://www.laboratorynotes.com/dna-damage-response-pathways/#respond Fri, 28 Aug 2026 06:16:01 +0000 https://www.laboratorynotes.com/?p=30059 ATM, ATR, DNA-PK, and p53 are key regulators of the DNA damage response. Learn how these pathways detect DNA damage, coordinate repair, control the cell cycle, and protect genome stability.

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