Retroviral restriction Archives - Laboratory Notes https://www.laboratorynotes.com/tag/retroviral-restriction/ Tue, 25 Aug 2026 07:31:25 +0000 en hourly 1 https://wordpress.org/?v=7.1 TRIM5α https://www.laboratorynotes.com/trim5%ce%b1/ https://www.laboratorynotes.com/trim5%ce%b1/#respond Tue, 25 Aug 2026 07:31:25 +0000 https://www.laboratorynotes.com/?p=29831 TRIM5α is a specialised antiviral ubiquitin ligase that recognises retroviral capsids, assembles K63‑linked ubiquitin chains and promotes autophagic degradation. Its tripartite motif and SPRY domain enable potent restriction of retroviruses, making TRIM5α a key factor in innate antiviral immunity and retroviral defence.

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