RING ligases. Ubiquitination Archives - Laboratory Notes https://www.laboratorynotes.com/tag/ring-ligases-ubiquitination/ Sun, 23 Aug 2026 19:07:22 +0000 en hourly 1 https://wordpress.org/?v=7.1 c‑Cbl https://www.laboratorynotes.com/c-cbl/ https://www.laboratorynotes.com/c-cbl/#respond Sun, 23 Aug 2026 19:07:22 +0000 https://www.laboratorynotes.com/?p=29816 c‑Cbl is a single‑chain RING finger ubiquitin ligase that regulates receptor tyrosine kinase signalling by binding phosphorylated RTKs and catalysing their ubiquitination. Through its TKB domain and RING domain, c‑Cbl controls EGFR turnover, immune signalling and cell growth. Mutations in c‑Cbl disrupt ubiquitination and contribute to myeloid malignancies, highlighting its importance in cellular homeostasis and disease.

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