RNF115 Archives - Laboratory Notes https://www.laboratorynotes.com/tag/rnf115/ Fri, 21 Aug 2026 09:51:17 +0000 en hourly 1 https://wordpress.org/?v=7.1 RNF115 (RING Finger Protein 115) https://www.laboratorynotes.com/rnf115-ring-finger-protein-115/ https://www.laboratorynotes.com/rnf115-ring-finger-protein-115/#respond Fri, 21 Aug 2026 09:51:17 +0000 https://www.laboratorynotes.com/?p=29796 RNF115 (BCA2) is a dual RING/U‑box E3 ubiquitin ligase that regulates membrane trafficking, innate immunity and antiviral defence. By ubiquitinating BST‑2/Tetherin, Rab7‑associated endosomal proteins and EGFR, RNF115 influences receptor turnover, immune signalling and cancer progression, making it a key regulator of cellular homeostasis.

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