Survivin Archives - Laboratory Notes https://www.laboratorynotes.com/tag/survivin/ Wed, 26 Aug 2026 07:51:58 +0000 en hourly 1 https://wordpress.org/?v=7.1.2 Aurora C https://www.laboratorynotes.com/aurora-c/ https://www.laboratorynotes.com/aurora-c/#respond Tue, 25 Aug 2026 23:24:06 +0000 https://www.laboratorynotes.com/?p=29881 Aurora C kinase is a germ‑cell‑enriched member of the Chromosomal Passenger Complex that safeguards meiotic chromosome segregation. By regulating kinetochore–microtubule interactions and cytokinesis, Aurora C ensures gamete quality and genomic stability. Its dysregulation contributes to infertility and tumour progression.

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]]> https://www.laboratorynotes.com/aurora-c/feed/ 0 Aurora B https://www.laboratorynotes.com/aurora-b/ https://www.laboratorynotes.com/aurora-b/#respond Tue, 25 Aug 2026 20:55:28 +0000 https://www.laboratorynotes.com/?p=29867 Aurora B kinase is the catalytic core of the Chromosomal Passenger Complex, ensuring accurate chromosome segregation, correcting kinetochore–microtubule attachment errors and coordinating cytokinesis. Its central role in mitotic fidelity and frequent dysregulation in cancer make Aurora B a major therapeutic target.

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]]> https://www.laboratorynotes.com/aurora-b/feed/ 0 Borealin https://www.laboratorynotes.com/borealin/ https://www.laboratorynotes.com/borealin/#respond Tue, 25 Aug 2026 19:38:10 +0000 https://www.laboratorynotes.com/?p=29865 Borealin (CDCA8) is the structural stabiliser of the Chromosomal Passenger Complex. By anchoring Aurora B, INCENP and Survivin to centromeres and guiding CPC relocation to the spindle midzone, Borealin ensures accurate chromosome segregation and successful cytokinesis.

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]]> https://www.laboratorynotes.com/borealin/feed/ 0 INCENP https://www.laboratorynotes.com/incenp/ https://www.laboratorynotes.com/incenp/#respond Tue, 25 Aug 2026 18:15:15 +0000 https://www.laboratorynotes.com/?p=29863 INCENP is the structural and regulatory scaffold of the Chromosomal Passenger Complex. By activating Aurora B kinase, binding microtubules and directing CPC movement from centromeres to the spindle midzone, INCENP ensures accurate chromosome segregation and successful cytokinesis.

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]]> https://www.laboratorynotes.com/incenp/feed/ 0 IAP Family https://www.laboratorynotes.com/iap-family/ https://www.laboratorynotes.com/iap-family/#respond Tue, 25 Aug 2026 06:52:39 +0000 https://www.laboratorynotes.com/?p=29840 The IAP family consists of intracellular proteins that regulate apoptosis, ubiquitination and immune signalling. Through their BIR domains and RING ligase activity, IAPs control caspase inhibition, NF‑κB activation, inflammasome signalling and tumour cell survival, making them central players in cell biology and cancer research.

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]]> https://www.laboratorynotes.com/iap-family/feed/ 0 Chromosomal Passenger Complex https://www.laboratorynotes.com/chromosomal-passenger-complex/ https://www.laboratorynotes.com/chromosomal-passenger-complex/#respond Mon, 24 Aug 2026 08:48:11 +0000 https://www.laboratorynotes.com/?p=29860 The Chromosomal Passenger Complex (CPC) is a dynamic mitotic regulator composed of Aurora B, INCENP, Borealin and Survivin. It ensures accurate chromosome segregation, corrects spindle attachment errors and coordinates cytokinesis, making it essential for genomic stability and highly relevant in cancer biology.

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]]> https://www.laboratorynotes.com/chromosomal-passenger-complex/feed/ 0 Survivin https://www.laboratorynotes.com/survivin/ https://www.laboratorynotes.com/survivin/#respond Mon, 24 Aug 2026 08:41:30 +0000 https://www.laboratorynotes.com/?p=29858 Survivin (BIRC5) is a tumour‑specific IAP that integrates apoptosis suppression with essential mitotic functions. As part of the chromosomal passenger complex, Survivin ensures proper chromosome segregation while stabilising anti‑apoptotic pathways, making it a central driver of tumour progression and therapy resistance.

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