Telomere shortening Archives - Laboratory Notes https://www.laboratorynotes.com/tag/telomere-shortening/ Wed, 26 Aug 2026 08:00:32 +0000 en hourly 1 https://wordpress.org/?v=7.1.2 Dyskeratosis Congenita https://www.laboratorynotes.com/dyskeratosis-congenita/ https://www.laboratorynotes.com/dyskeratosis-congenita/#respond Sat, 22 Aug 2026 16:52:52 +0000 https://www.laboratorynotes.com/?p=29760 Dyskeratosis congenita is a rare inherited telomere‑maintenance disorder caused by mutations in DKC1, TERT, TERC and POT1. Accelerated telomere shortening leads to premature cellular ageing, bone‑marrow failure, mucocutaneous abnormalities and multisystem disease. The condition provides key insight into how telomere biology shapes human ageing and tissue regeneration.

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]]> https://www.laboratorynotes.com/dyskeratosis-congenita/feed/ 0 Premature Ageing https://www.laboratorynotes.com/premature-ageing/ https://www.laboratorynotes.com/premature-ageing/#comments Thu, 20 Aug 2026 19:46:08 +0000 https://www.laboratorynotes.com/?p=29753 Premature ageing describes the accelerated decline of cellular and physiological functions caused by genomic instability, telomere attrition, mitochondrial dysfunction and chronic inflammation. These processes activate ageing pathways earlier than expected, leading to early onset of tissue deterioration, reduced homeostasis and increased vulnerability to age‑related diseases.

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]]> https://www.laboratorynotes.com/premature-ageing/feed/ 1 Ageing https://www.laboratorynotes.com/ageing/ https://www.laboratorynotes.com/ageing/#comments Thu, 20 Aug 2026 19:20:48 +0000 https://www.laboratorynotes.com/?p=29749 Ageing is a gradual biological process driven by genomic instability, telomere shortening, mitochondrial dysfunction and cellular senescence. These changes reduce physiological resilience, impair tissue repair and increase susceptibility to chronic disease. Understanding the mechanisms of ageing provides insight into longevity, healthspan and the development of age‑related disorders.

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