XBP1 splicing Archives - Laboratory Notes https://www.laboratorynotes.com/tag/xbp1-splicing/ Thu, 27 Aug 2026 00:01:37 +0000 en hourly 1 https://wordpress.org/?v=7.1 IRE1 https://www.laboratorynotes.com/ire1/ https://www.laboratorynotes.com/ire1/#respond Thu, 27 Aug 2026 00:01:37 +0000 https://www.laboratorynotes.com/?p=30001 IRE1 is the most conserved ER stress sensor, activating XBP1 splicing and RIDD to restore proteostasis. Through its kinase and RNase activities, IRE1 detects misfolded proteins, initiates adaptive signalling and coordinates the unfolded protein response during ER stress.

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