Category: Database: Disease
Post‑Micturition Dribble
Post‑micturition dribble (PMD) is a frequently overlooked urinary symptom in which small amounts of urine leak after a person finishes urinating. Although not medically dangerous, PMD can be uncomfortable and socially inconvenient. It often results from residual urine trapped in the urethra, pelvic floor weakness, or functional changes in the urinary tract. This article provides a concise overview of the major aspects of PMD, each of which will be expanded into detailed articles later.
Hyperinsulinemia
Hyperinsulinemia is a condition characterized by elevated circulating insulin levels. It commonly develops as a compensatory response to insulin resistance, allowing the pancreas to produce more insulin to maintain glucose homeostasis. Understanding hyperinsulinemia provides insight into insulin signaling, glucose and lipid metabolism, obesity, metabolic syndrome, prediabetes, and type 2 diabetes.
Hutchinson–Gilford Progeria Syndrome
Hutchinson–Gilford progeria syndrome is a rare genetic disorder caused by LMNA mutations that generate progerin, a toxic protein disrupting nuclear structure and accelerating ageing. Children develop rapid cardiovascular decline, growth failure and systemic tissue deterioration, making HGPS one of the most important models for understanding human ageing.
Sertoli Cell‑Only Syndrome
Sertoli‑cell‑only syndrome is a severe testicular disorder in which seminiferous tubules contain only Sertoli cells and no germ cells. Caused by AZFa microdeletions, germ‑cell developmental gene mutations or acquired testicular injury, SCOS represents an advanced form of non‑obstructive azoospermia with major implications for fertility and genetic counselling.