Laboratory Notes

Express relatively high level of p53 and p21 Undergo senescence (early passage cells) Post-mitotic tetraploid cell-cycle arrest and polyploidy Aberrant…

Embryonic lethal, die between E11.5 and E12.5 (Grisendi et al., 2005)

qPCR primers for Mouse β-Actin Source: Li et al., 2008. supplementary information Forward Primer: 5’-GCTGTGCTATGTTGCTCTAG-3’ Reverse Primer:  5’-CGCTCGTTGCCAATAGTG-3’ #

qPCR primers for Mouse ELF1a Source: Li et al., 2008. supplementary information Forward Primer: 5’-AAAATTGGCTACAACCCCGA-3’ Reverse Primer:  5’-CCAACCAGAAATTGGCACAA-3’ #

qPCR primers for Mouse GAS1 Source: Li et al., 2008. supplementary information Forward Primer: 5’-TCCCCTTACCGATTCATTCCT-3’ Reverse Primer:  5’-CAATCGCCAGCTCCACACT-3’ #

qPCR primers for Mouse EIF4E Source: Li et al., 2008. supplementary information Forward Primer: 5’-GGACGGGATTGAGCCTATGTG-3’ Reverse Primer:  5’-CAGCAGTGTCTCTAGCCAGAAG-3’ #

CDK4 primers for Mouse Nucleolin Source: Li et al., 2008. supplementary information Forward Primer: 5’-GCAGTCTACATACGCAACAC-3’ Reverse Primer:  5’-TCGTCTTCTGGAGGCAATC-3’ #

qPCR primers for Mouse Nucleolin Source: Li et al., 2008. supplementary information Forward Primer: 5′-ACACCAGCCAAAGTCATTCC-3′ Reverse Primer:  5′-ATCCTCATCACTGTCTTCCTTC-3′ #

NPM is important for the oncogenic functions of c-Myc. Its overexpression enhances the hyperproliferation and transformation driven by c-Myc, while…

Nucleophosmin (NPM) plays a significant role in cell transformation, particularly through its interaction with c-Myc. In their 2008 study, Li…

Note: The protein nucleophosmin is commonly referred to as NPM or NPM1 in the literature. Nucleophosmin can enhance cell proliferation. …

The nucleolus is the most prominent membrane-less subnuclear structure found in all eukaryotic cells during interphase, although it disappears during…

Note: The protein nucleophosmin is commonly referred to as NPM or NPM1 in the literature. The protein Nucleophosmin is primarily…

Synonyms: Nucleophosmin/B23 Nucleophosmin Numatrin B23 NPM NPM1 NO38 Note: NPM1 is commonly referred to as nucleophosmin, while other nucleophosmins like…

Large subunit of Origin Recognition Complex (ORC) Play role in initiation of replication of genomic DNA In humans, ORC1 is…