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Hepatocytes

Hepatocytes are the cells found in the liver. They are highly differentiated cells but retain the potential to proliferate. In…

List of Tumors/Cancers Expressing High Levels of Cyclin D

The following tumors/cancers have been reported to express high levels of D-type cyclins. This is not a complete list. We…

Topic: Cyclin D

Cyclin D Cyclin D in Cancer List of Tumors/Cancers Expressing High Levels of Cyclin D List of Cyclin D-CDK4/6 Substrates…

Topic: MCF7 Cell Line

Cell Line: MCF7 ExpSup: Serum Stimulation Induces p21 Transcription in Serum-starved MCF7 Cells ExpSup: IL6 does not Induce p21 Transcription…

ExpSup: IL6 Induces p21 Transcription in Serum-starved HepG2 Cells

Bienvenu and coworkers analyzed the expression of p21 in serum-starved HepG2 cells upon IL6 stimulation. HepG2 Cells were serum starved…

ExpSup: Serum Stimulation Induces p21 Transcription in Serum-starved MCF7 Cells

Bienvenu and coworkers analyzed the expression of p21 in serum-starved MCF7 cells upon serum stimulation. Serum-starved MCF7 cells for 2…

ExpSup: IL6 does not Induce p21 Transcription in Serum-starved MCF7 Cells

Bienvenu and coworkers analyzed the expression of p21 in serum-starved MCF7 cells upon IL6 stimulation. Serum-starved MCF7 cells for 2…

List of Cell Lines Expressing High Levels of Cyclin D1

The following cell lines express relatively high levels of cyclin D1. MCF7 REFERENCES: Bienvenu et al., 2005. Transcriptional regulation by…

LY294002

Cas Noumber: 154447-36-6 Activities: Potent inhibitor of phosphoinositide 3-kinases (PI3Ks) Although it is a potent inhibitor of PI3K, it is…

Interaction of Cyclin D1 with STAT3

Cyclin D1 has been shown to interact with STAT3.  This interaction is not direct and is mediated by NcoA/SRC1a (Bienvenu…

ExpSup: Cyclin D1 Inhibits p21 Gene Transcription

HepG2 cells stably expressing Cyclin D1 show a reduced level of p21 expression (both mRNA and protein) as compared to…

ExpSup: IL6 Induces p21 Transcription in Serum-Starved HepG2 Cell Line

Bienvenu and coworkers showed that stimulation of serum-starved HepG2 cells with IL6 induces p21 expression (Bienvenu et al., 2005). They…

Cyclin D in Cancer

Well-established oncogene  Driver of tumors  May confer resistance to chemotherapy Cyclin D overexpression, accumulation, and mislocalization have been reported in…

Activation of CDK4/6 in G1 Phase

Cyclin-dependent kinases CDK4 and CDK6 (CDK4/6) play important roles in controlling the G1 phase progression, particularly passing the cells through…