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Hepatocytes are the cells found in the liver. They are highly differentiated cells but retain the potential to proliferate. In…

The following tumors/cancers have been reported to express high levels of D-type cyclins. This is not a complete list. We…

Cyclin D Cyclin D in Cancer List of Tumors/Cancers Expressing High Levels of Cyclin D List of Cyclin D-CDK4/6 Substrates…

Cell Line: MCF7 ExpSup: Serum Stimulation Induces p21 Transcription in Serum-starved MCF7 Cells ExpSup: IL6 does not Induce p21 Transcription…

Bienvenu and coworkers analyzed the expression of p21 in serum-starved HepG2 cells upon IL6 stimulation. HepG2 Cells were serum starved…

Bienvenu and coworkers analyzed the expression of p21 in serum-starved MCF7 cells upon serum stimulation. Serum-starved MCF7 cells for 2…

Bienvenu and coworkers analyzed the expression of p21 in serum-starved MCF7 cells upon IL6 stimulation. Serum-starved MCF7 cells for 2…

The following cell lines express relatively high levels of cyclin D1. MCF7 REFERENCES: Bienvenu et al., 2005. Transcriptional regulation by…

Wortmannin LY294002

Cas Noumber: 154447-36-6 Activities: Potent inhibitor of phosphoinositide 3-kinases (PI3Ks) Although it is a potent inhibitor of PI3K, it is…

Cyclin D1 has been shown to interact with STAT3.  This interaction is not direct and is mediated by NcoA/SRC1a (Bienvenu…

HepG2 cells stably expressing Cyclin D1 show a reduced level of p21 expression (both mRNA and protein) as compared to…

Bienvenu and coworkers showed that stimulation of serum-starved HepG2 cells with IL6 induces p21 expression (Bienvenu et al., 2005). They…

Well-established oncogene  Driver of tumors  May confer resistance to chemotherapy Cyclin D overexpression, accumulation, and mislocalization have been reported in…

Cyclin-dependent kinases CDK4 and CDK6 (CDK4/6) play important roles in controlling the G1 phase progression, particularly passing the cells through…