Category: Database: Gene/Protein
Shelterin
Shelterin is a protein complex that protects telomeres and maintains chromosome stability. This article explains its structure, components, and essential role in telomere regulation and DNA damage prevention.
VBC Complex
The VBC complex—composed of von Hippel–Lindau protein (pVHL), elongin B, and elongin C—is a multiprotein assembly that plays a pivotal…
RING-box protein 1 (Rbx1)
RING-box protein 1 (Rbx1) (RING-box protein 1), also known as ROC1 or RBX1, is a small but essential protein that…
Cullin-2 (CUL2)
Cullin-2 (CUL2) is a member of the cullin family of scaffold proteins that form the structural backbone of Cullin–RING ubiquitin…
Elongin C
Elongin C is a small adaptor protein that functions as a core component of several multiprotein complexes involved in transcriptional…
Elongin B
Elongin B is a small, ubiquitously expressed protein that functions as a regulatory and adaptor subunit in multiple multiprotein complexes. …
Hypoxia-Inducible Factor Alpha (HIF-α)
Hypoxia-inducible factor alpha (HIF-α) is the oxygen-sensitive subunit of the hypoxia-inducible factor (HIF) transcriptional complex, which serves as the master…
Elongin A
Elongin A is a transcription elongation factor that plays a key role in enhancing the rate and efficiency of RNA…
Placental Growth Factor-2 (PlGF-2)
Placental growth factor-2 (PlGF-2) is a splice variant of placental growth factor (PlGF), a member of the vascular endothelial growth…
Placental Growth Factor-1 (PlGF-1)
Placental growth factor-1 (PlGF-1) is one of the major isoforms of placental growth factor (PlGF), a member of the vascular…
Semaphorin 3A (Sema3A)
Semaphorin 3A (Sema3A) is a secreted glycoprotein that belongs to the class 3 semaphorins, a family of signaling molecules originally…
Prolyl Hydroxylase Domain Protein 3 (PHD3)
Prolyl hydroxylase domain protein 3 (PHD3), also known as EGLN3, is one of the three main isoforms of the prolyl…
Prolyl Hydroxylase Domain Protein 2 (PHD2)
Prolyl hydroxylase domain protein 2 (PHD2), also known as EGLN1, is the most critical and widely expressed isoform of the…
Prolyl Hydroxylase Domain Protein 1 (PHD1)
Prolyl hydroxylase domain protein 1 (PHD1), also known as EGLN2 (Egl-9 homolog 2), is one of the three major isoforms…
Prolyl Hydroxylase Domain (PHD) Protein
Prolyl hydroxylase domain proteins (PHDs), also known as EGLNs (Egl-9 homologs), are a family of oxygen-, iron-, and 2-oxoglutarate–dependent dioxygenases…