Category: Lab Notes: Cell Biology
Vimentin in Epithelial-to-Mesenchymal Transition (EMT)
Vimentin is a type III intermediate filament protein that plays a pivotal role in the structural reorganization and phenotypic transformation…
E-cadherin in Epithelial-to-Mesenchymal Transition (EMT)
E-cadherin, or epithelial cadherin, is a transmembrane glycoprotein that plays a fundamental role in maintaining the structure and integrity of…
Matrix Metalloproteinase-3 (MMP-3) in Epithelial-to-Mesenchymal transition (EMT)
Matrix metalloproteinase-3 (MMP-3), also known as stromelysin-1, plays an important role in the induction and progression of epithelial-to-mesenchymal transition (EMT),…
Exocytosis
Exocytosis is a cellular process where materials are transported out of the cell via membrane-bound vesicles that fuse with the…
Membrane Recycling
Membrane recycling is a crucial cellular process that involves the continuous internalization, sorting, and reuse of membrane components and associated…
Vesicle Trafficking
Vesicle trafficking is a fundamental cellular process that orchestrates the organized movement of membrane-bound compartments within cells, enabling the transport…
Endocytosis
Endocytosis is a fundamental cellular process through which cells internalize substances from their external environment by forming membrane-bound vesicles. This…
Key Indicators for Monitoring Epithelial-to-Mesenchymal Transition (EMT)
Feature Epithelial Mesenchymal Remarks Morphology Cobblestone-like Spindle-shaped, motile Morphological shift is often the first visible sign of EMT. E-cadherin High…
Tools for Studying Epithelial-to-Mesenchymal Transition (EMT)
Epithelial-to-mesenchymal transition (EMT) can be studied through a multidisciplinary approach that integrates morphological assessment, gene expression analysis, and functional assays,…
Mesenchymal Stem Cell (MSC) Markers
Mesenchymal stem cells (MSCs) are multipotent stromal cells capable of differentiating into various cell types, including osteoblasts, adipocytes, and chondrocytes. …
Mesenchymal Markers
Mesenchymal markers are proteins commonly expressed by mesenchymal cells — cells that are typically spindle-shaped, motile, and found in connective…
Epithelial Polarity
Epithelial polarity refers to the distinct distribution of cellular structures and functions within epithelial cells, which line surfaces and cavities…
Endosome
Endosomes are dynamic membrane-bound organelles that play central roles in cellular trafficking, protein sorting, and signal transduction. These compartments form…
Apical-Basal Polarity
Apical-basal polarity is a fundamental feature of epithelial cells that establishes distinct membrane domains and cellular organization along the apical-basal…
Membrane Trafficking
Membrane trafficking is a fundamental cellular process that involves the movement of proteins, lipids, and other molecules between different cellular…