Tag: Anaphase-promoting complex/cyclosome
Cdh1
Cdh1 is a major activator of the APC/C complex, responsible for mitotic exit, G1 maintenance and replication licensing. By degrading Cyclin B, Aurora A, Plk1 and Geminin, Cdh1 prevents premature S‑phase entry and maintains genomic stability. Its dysregulation contributes to replication stress, chromosomal instability and cancer development.
Anaphase-Promoting Complex/Cyclosome (APC/C)
The Anaphase-promoting complex/cyclosome (APC/C) is a large multi-subunit E3 ubiquitin ligase that plays a crucial role in cell cycle regulation….
Cdh1
Cdh1 is a major activator of the APC/C complex, responsible for mitotic exit, G1 maintenance and replication licensing. By degrading Cyclin B, Aurora A, Plk1 and Geminin, Cdh1 prevents premature S‑phase entry and maintains genomic stability. Its dysregulation contributes to replication stress, chromosomal instability and cancer development.
Anaphase-Promoting Complex/Cyclosome (APC/C)
The Anaphase-promoting complex/cyclosome (APC/C) is a large multi-subunit E3 ubiquitin ligase that plays a crucial role in cell cycle regulation….