Tag: Antiviral defence
TRIM Family
The TRIM family is a large group of single‑chain RING finger ubiquitin ligases that regulate innate immunity, antiviral defence, autophagy, transcription and protein quality control. Defined by their tripartite motif—RING, B‑box and coiled‑coil domains—TRIM proteins use diverse C‑terminal regions to achieve precise substrate specificity. Their roles in immunity, development and cancer make them key regulators of cellular homeostasis.
RNF115 (RING Finger Protein 115)
RNF115 (BCA2) is a dual RING/U‑box E3 ubiquitin ligase that regulates membrane trafficking, innate immunity and antiviral defence. By ubiquitinating BST‑2/Tetherin, Rab7‑associated endosomal proteins and EGFR, RNF115 influences receptor turnover, immune signalling and cancer progression, making it a key regulator of cellular homeostasis.
TRIM Family
The TRIM family is a large group of single‑chain RING finger ubiquitin ligases that regulate innate immunity, antiviral defence, autophagy, transcription and protein quality control. Defined by their tripartite motif—RING, B‑box and coiled‑coil domains—TRIM proteins use diverse C‑terminal regions to achieve precise substrate specificity. Their roles in immunity, development and cancer make them key regulators of cellular homeostasis.
RNF115 (RING Finger Protein 115)
RNF115 (BCA2) is a dual RING/U‑box E3 ubiquitin ligase that regulates membrane trafficking, innate immunity and antiviral defence. By ubiquitinating BST‑2/Tetherin, Rab7‑associated endosomal proteins and EGFR, RNF115 influences receptor turnover, immune signalling and cancer progression, making it a key regulator of cellular homeostasis.