Tag: Antiviral immunity
TRIM5α
TRIM5α is a specialised antiviral ubiquitin ligase that recognises retroviral capsids, assembles K63‑linked ubiquitin chains and promotes autophagic degradation. Its tripartite motif and SPRY domain enable potent restriction of retroviruses, making TRIM5α a key factor in innate antiviral immunity and retroviral defence.
TRIM21
TRIM21 is a unique intracellular antibody receptor and RING finger ubiquitin ligase that neutralises antibody‑coated viruses inside the cytosol. Through its PRY/SPRY domain and tripartite motif, TRIM21 triggers rapid ubiquitin‑mediated degradation and activates antiviral signalling pathways. Its roles in immunity, autoimmunity and biotechnology make TRIM21 a key regulator of intracellular defence.
TRIM25
TRIM25 is a RING finger ubiquitin ligase that activates the antiviral sensor RIG‑I through K63‑linked ubiquitination. Its tripartite motif and PRY/SPRY domain enable precise regulation of innate immune signalling, interferon production and viral restriction. TRIM25 is targeted by multiple viruses, highlighting its importance as a frontline antiviral factor.
TRIM5α
TRIM5α is a specialised antiviral ubiquitin ligase that recognises retroviral capsids, assembles K63‑linked ubiquitin chains and promotes autophagic degradation. Its tripartite motif and SPRY domain enable potent restriction of retroviruses, making TRIM5α a key factor in innate antiviral immunity and retroviral defence.
TRIM21
TRIM21 is a unique intracellular antibody receptor and RING finger ubiquitin ligase that neutralises antibody‑coated viruses inside the cytosol. Through its PRY/SPRY domain and tripartite motif, TRIM21 triggers rapid ubiquitin‑mediated degradation and activates antiviral signalling pathways. Its roles in immunity, autoimmunity and biotechnology make TRIM21 a key regulator of intracellular defence.
TRIM25
TRIM25 is a RING finger ubiquitin ligase that activates the antiviral sensor RIG‑I through K63‑linked ubiquitination. Its tripartite motif and PRY/SPRY domain enable precise regulation of innate immune signalling, interferon production and viral restriction. TRIM25 is targeted by multiple viruses, highlighting its importance as a frontline antiviral factor.