Tag: Autoimmunity

Protein citrullination is a calcium-dependent post-translational modification that converts arginine into citrulline. Explore PAD enzymes, histone citrullination, NETosis, inflammation, rheumatoid arthritis, autoimmunity, cancer, and citrullination proteomics.

Cbl‑b is a single‑chain RING finger ubiquitin ligase that acts as a master regulator of immune activation. By ubiquitinating key signalling molecules in T‑cells, B‑cells and NK cells, Cbl‑b maintains immune tolerance and prevents hyperactivation. Loss of Cbl‑b leads to autoimmunity and enhanced anti‑tumour immunity, making it a critical player in immune homeostasis and a promising target in cancer immunotherapy.