Tag: c‑Cbl
CBL Family Ubiquitin Ligase
The CBL family of ubiquitin ligases—c‑Cbl, Cbl‑b and Cbl‑c—are single‑chain RING finger E3 enzymes that regulate receptor tyrosine kinase signalling, immune activation and epithelial homeostasis. Through their TKB and RING domains, CBL proteins control ubiquitination, endocytosis and signal attenuation. Dysregulation of CBL ligases contributes to cancer, autoimmunity and inflammatory disorders, highlighting their importance in cellular regulation and disease.
c‑Cbl
c‑Cbl is a single‑chain RING finger ubiquitin ligase that regulates receptor tyrosine kinase signalling by binding phosphorylated RTKs and catalysing their ubiquitination. Through its TKB domain and RING domain, c‑Cbl controls EGFR turnover, immune signalling and cell growth. Mutations in c‑Cbl disrupt ubiquitination and contribute to myeloid malignancies, highlighting its importance in cellular homeostasis and disease.
CBL Family Ubiquitin Ligase
The CBL family of ubiquitin ligases—c‑Cbl, Cbl‑b and Cbl‑c—are single‑chain RING finger E3 enzymes that regulate receptor tyrosine kinase signalling, immune activation and epithelial homeostasis. Through their TKB and RING domains, CBL proteins control ubiquitination, endocytosis and signal attenuation. Dysregulation of CBL ligases contributes to cancer, autoimmunity and inflammatory disorders, highlighting their importance in cellular regulation and disease.
c‑Cbl
c‑Cbl is a single‑chain RING finger ubiquitin ligase that regulates receptor tyrosine kinase signalling by binding phosphorylated RTKs and catalysing their ubiquitination. Through its TKB domain and RING domain, c‑Cbl controls EGFR turnover, immune signalling and cell growth. Mutations in c‑Cbl disrupt ubiquitination and contribute to myeloid malignancies, highlighting its importance in cellular homeostasis and disease.