Tag: Caspase inhibition
XIAP
XIAP is the most potent endogenous inhibitor of caspases and a central regulator of apoptosis and immune signalling. Through its BIR domains and RING ubiquitin ligase activity, XIAP blocks caspase‑3, caspase‑7 and caspase‑9 while modulating NF‑κB pathways, making it a key player in cancer, inflammation and immune disorders.
XIAP
XIAP is the most potent endogenous inhibitor of caspases and a central regulator of apoptosis and immune signalling. Through its BIR domains and RING ubiquitin ligase activity, XIAP blocks caspase‑3, caspase‑7 and caspase‑9 while modulating NF‑κB pathways, making it a key player in cancer, inflammation and immune disorders.