Tag: Cell signalling

Cell signalling pathways are the communication networks that allow cells to detect signals, activate molecular cascades, and coordinate essential functions. This article explains how signalling works, how pathways are activated, and why they are vital for cellular health and survival.

c‑Cbl is a single‑chain RING finger ubiquitin ligase that regulates receptor tyrosine kinase signalling by binding phosphorylated RTKs and catalysing their ubiquitination. Through its TKB domain and RING domain, c‑Cbl controls EGFR turnover, immune signalling and cell growth. Mutations in c‑Cbl disrupt ubiquitination and contribute to myeloid malignancies, highlighting its importance in cellular homeostasis and disease.