Tag: Centromere
Kinetochore
The kinetochore is a dynamic protein complex assembled on centromeric chromatin that binds spindle microtubules, generates tension and ensures accurate chromosome segregation. Through coordinated interactions with Aurora B kinase and spindle checkpoint signalling, the kinetochore maintains mitotic fidelity and prevents aneuploidy.
Kinetochore
The kinetochore is a dynamic protein complex assembled on centromeric chromatin that binds spindle microtubules, generates tension and ensures accurate chromosome segregation. Through coordinated interactions with Aurora B kinase and spindle checkpoint signalling, the kinetochore maintains mitotic fidelity and prevents aneuploidy.