Tag: Chromosomal instability

Aurora A kinase is a key regulator of centrosome maturation and spindle assembly. By controlling microtubule dynamics, centrosome separation and chromosome alignment, Aurora A ensures accurate mitotic progression. Its frequent overexpression in cancer highlights its importance in genomic stability and tumour development.

Genomic instability describes the increased tendency of cells to accumulate genetic alterations due to failures in DNA repair, replication fidelity, and chromosome segregation. It plays a central role in cancer development, ageing, and hereditary disorders.