PERK is a central ER stress sensor that phosphorylates eIF2α, reduces protein synthesis and activates ATF4‑dependent transcription. Through adaptive and apoptotic signalling, PERK coordinates unfolded protein response pathways that restore proteostasis or eliminate irreparably damaged cells.
PERK is a central ER stress sensor that phosphorylates eIF2α, reduces protein synthesis and activates ATF4‑dependent transcription. Through adaptive and apoptotic signalling, PERK coordinates unfolded protein response pathways that restore proteostasis or eliminate irreparably damaged cells.
