Tag: G0 phase

Terminally differentiated cells are highly specialized cells that have undergone a differentiation program and generally withdraw permanently from productive cell division. This article explains the molecular mechanisms of terminal differentiation, its relationship with cell-cycle exit, and the differences between terminal differentiation, quiescence, and cellular senescence.

Cellular quiescence is a reversible non-proliferative state in which cells temporarily withdraw from the active cell cycle while remaining viable and metabolically active. This article explores the molecular mechanisms regulating quiescence, its relationship with the G₀ phase, cell-cycle re-entry, stem-cell maintenance, metabolism, transcription, and cellular quality control, as well as its distinction from senescence and terminal differentiation.