Tag: Genomic stability

Cdh1 is a major activator of the APC/C complex, responsible for mitotic exit, G1 maintenance and replication licensing. By degrading Cyclin B, Aurora A, Plk1 and Geminin, Cdh1 prevents premature S‑phase entry and maintains genomic stability. Its dysregulation contributes to replication stress, chromosomal instability and cancer development.

Cell‑cycle checkpoints act as surveillance systems that monitor DNA integrity, replication completeness and spindle attachment. The G1, G2 and spindle checkpoints prevent cells with damage or misaligned chromosomes from dividing, ensuring accurate genome transmission and protecting against genomic instability and cancer.

The S phase is the period of the cell cycle in which DNA is replicated, producing identical copies of the genome for distribution to daughter cells. It is tightly regulated to maintain accuracy and prevent genomic instability.

Cellular homeostasis is the dynamic process that maintains internal stability by regulating ions, metabolism, proteostasis, organelle function and genomic integrity. Through coordinated signalling networks and adaptive stress responses, cells preserve equilibrium and protect themselves from dysfunction and disease.