Tag: K48‑linked ubiquitination
HECT Ubiquitin Ligase
HECT ubiquitin ligases are catalytic E3 enzymes that form a thioester intermediate with ubiquitin, allowing precise control of ubiquitin‑chain architecture. Through NEDD4‑family ligases, HERC proteins and HUWE1, the HECT class regulates receptor endocytosis, DNA‑damage signalling, proteostasis and diverse cellular stress responses.
K48‑Linked Ubiquitination
K48‑linked ubiquitination is the principal degradation signal in eukaryotic cells, directing proteins to the 26S proteasome. Built by E1, E2 and E3 enzymes, K48‑linked chains regulate protein turnover, cell‑cycle progression and DNA‑damage responses, forming a central mechanism for maintaining proteostasis and preventing toxic protein accumulation.
HECT Ubiquitin Ligase
HECT ubiquitin ligases are catalytic E3 enzymes that form a thioester intermediate with ubiquitin, allowing precise control of ubiquitin‑chain architecture. Through NEDD4‑family ligases, HERC proteins and HUWE1, the HECT class regulates receptor endocytosis, DNA‑damage signalling, proteostasis and diverse cellular stress responses.
K48‑Linked Ubiquitination
K48‑linked ubiquitination is the principal degradation signal in eukaryotic cells, directing proteins to the 26S proteasome. Built by E1, E2 and E3 enzymes, K48‑linked chains regulate protein turnover, cell‑cycle progression and DNA‑damage responses, forming a central mechanism for maintaining proteostasis and preventing toxic protein accumulation.