Tag: MRN complex

RAD50 is the structural architect of the MRN complex and an essential stabiliser of DNA double‑strand breaks. Through ATP‑dependent conformational changes and zinc‑hook‑mediated DNA tethering, RAD50 coordinates MRE11 and NBS1 to ensure accurate DNA repair and maintain genome stability.

MRE11 is the core nuclease of the MRN complex and a master regulator of DNA double‑strand break repair. By initiating DNA end resection, activating ATM signalling and stabilising damaged chromosomes, MRE11 plays a central role in maintaining genome stability and preventing chromosomal instability.

The MRN complex, composed of MRE11, RAD50 and NBS1, is the primary sensor of DNA double‑strand breaks and a central regulator of genome stability. By activating ATM, initiating homologous recombination and stabilising damaged chromosomes, MRN safeguards cells against genomic instability and disease.