Tag: Oncogenesis

Tumorigenesis is the complex process through which normal cells acquire malignant characteristics. Explore the major genetic, epigenetic, cellular, metabolic, immunological, and environmental mechanisms involved in cancer development and progression.

Mdm2 is a RING‑type E3 ubiquitin ligase that controls p53 stability through ubiquitination, nuclear export and proteasomal degradation. By interacting with p53, Mdmx/Mdm4 and ARF, Mdm2 regulates DNA‑damage responses, cell‑cycle progression and oncogenesis, making it a central determinant of tumour development and genome stability.

Cancer is a multifaceted disease caused by the uncontrolled growth of abnormal cells. It develops through genetic and epigenetic alterations, environmental exposures, and interactions within the tumour microenvironment. Understanding these processes is essential for improving prevention, diagnosis, and treatment.