The DNA damage response is a cellular defense system that detects DNA damage, coordinates repair, regulates cell-cycle checkpoints, and protects the stability of the genome.
ATR is a key protein kinase that protects cells from replication stress and DNA damage. Explore how ATR detects single-stranded DNA, stabilizes replication forks, activates CHK1, and maintains genome stability.
Replication stress occurs when DNA replication forks stall or collapse, generating genomic instability and driving tumour evolution. Through ATR–CHK1 signalling, fork protection and homologous recombination repair, cells stabilise damaged forks and prevent catastrophic chromosomal breakage.
BRCA1 is a central tumour‑suppressor protein that regulates homologous recombination, DNA end resection and checkpoint signalling. By coordinating high‑fidelity DNA repair and protecting replication forks, BRCA1 maintains genome stability and prevents oncogenic transformation.
ATM, ATR, DNA-PK, and p53 are key regulators of the DNA damage response. Learn how these pathways detect DNA damage, coordinate repair, control the cell cycle, and protect genome stability.
The DNA damage response is a cellular defense system that detects DNA damage, coordinates repair, regulates cell-cycle checkpoints, and protects the stability of the genome.
ATR is a key protein kinase that protects cells from replication stress and DNA damage. Explore how ATR detects single-stranded DNA, stabilizes replication forks, activates CHK1, and maintains genome stability.
Replication stress occurs when DNA replication forks stall or collapse, generating genomic instability and driving tumour evolution. Through ATR–CHK1 signalling, fork protection and homologous recombination repair, cells stabilise damaged forks and prevent catastrophic chromosomal breakage.
BRCA1 is a central tumour‑suppressor protein that regulates homologous recombination, DNA end resection and checkpoint signalling. By coordinating high‑fidelity DNA repair and protecting replication forks, BRCA1 maintains genome stability and prevents oncogenic transformation.
ATM, ATR, DNA-PK, and p53 are key regulators of the DNA damage response. Learn how these pathways detect DNA damage, coordinate repair, control the cell cycle, and protect genome stability.
