Tag: Restriction point
Retinoblastoma Protein (pRb)
pRb is a major tumour‑suppressor that governs the G1–S transition by restraining E2F transcription factors and maintaining a repressive chromatin state. When pRb becomes hyperphosphorylated, cells commit to DNA replication. Loss of pRb function leads to uncontrolled proliferation, replication stress and genomic instability, making it a key player in cancer development.
Retinoblastoma Protein (pRb)
pRb is a major tumour‑suppressor that governs the G1–S transition by restraining E2F transcription factors and maintaining a repressive chromatin state. When pRb becomes hyperphosphorylated, cells commit to DNA replication. Loss of pRb function leads to uncontrolled proliferation, replication stress and genomic instability, making it a key player in cancer development.