Tag: Spliceosome

SmB and SmB′ are closely related spliceosomal proteins produced from the SNRPB gene. Learn how these Sm proteins contribute to the Sm ring, snRNP assembly, U1 snRNP structure, and accurate pre-mRNA splicing.

SmD2 is one of the seven canonical Sm proteins found in major spliceosomal snRNPs. Discover how SmD2 contributes to Sm ring formation, snRNP assembly, spliceosome function, and RNA splicing.

SmD1 is one of the seven canonical Sm proteins that form the conserved Sm ring in major spliceosomal snRNPs. Learn how SmD1 supports snRNP assembly, stability, spliceosome function, and RNA splicing.

SmD3 is one of the seven canonical Sm proteins that form the conserved Sm ring in major spliceosomal snRNPs. Learn how SmD3 contributes to snRNP assembly, stability, spliceosome function, and RNA splicing.

SmE is one of the seven canonical Sm proteins found in major spliceosomal snRNPs. Discover how SmE contributes to Sm ring formation, snRNP assembly, spliceosome function, and RNA splicing.

SmF is one of the seven canonical Sm proteins that form the structural core of several spliceosomal snRNPs. This article explains SmF structure and function, its role in Sm ring formation and snRNP assembly, and its relationship with U1 snRNP and RNA splicing.

Sm proteins form a conserved structural core of several spliceosomal snRNPs, including U1 snRNP. Learn how Sm proteins interact with snRNA, support snRNP assembly and stability, and contribute to spliceosome formation and RNA splicing.

U1C is a key protein component of U1 snRNP that helps stabilize the complex and support 5′ splice-site recognition during early spliceosome assembly. Learn how U1C works with U1 snRNA and other U1 proteins to initiate RNA splicing and contribute to accurate pre-mRNA processing.

U1-70K is an important protein component of U1 snRNP that supports the early stages of spliceosome assembly and 5′ splice-site recognition. Explore its structure, interactions, role in RNA splicing, and relevance to abnormal splicing.

Mutually exclusive exons are a specialized form of alternative RNA splicing in which a mature RNA transcript contains one exon from a pair or group while excluding the others. This mechanism allows cells to regulate gene expression and generate different RNA transcripts and protein isoforms from the same gene.

U1 snRNA is the RNA component of U1 snRNP and plays a key role in recognizing the 5′ splice site during pre-mRNA splicing. Explore its structure, sequence, RNA-RNA base pairing, spliceosome function, and role in alternative splicing.

U1 snRNP is an early component of the spliceosome that recognizes the 5′ splice site of pre-mRNA. Learn how U1 snRNA and associated proteins help initiate spliceosome assembly, regulate splice-site selection, and support accurate RNA splicing.

The 5′ splice site, also called the donor splice site, marks the beginning of an intron and helps U1 snRNP recognize the correct RNA-splicing boundary. Learn how it works with the spliceosome, branch point, and 3′ splice site during intron removal.

U2AF is an important RNA-splicing factor that helps recognize the 3′ end of many introns. Learn how U2AF65 and U2AF35 interact with the polypyrimidine tract and 3′ splice site and help coordinate spliceosome assembly during pre-mRNA processing.

The polypyrimidine tract is a U- and C-rich sequence near the 3′ end of many introns that helps the spliceosome recognize the 3′ splice site. Learn how it works with the branch point, splicing factors, and other RNA signals to regulate RNA splicing and gene expression.