Tag: TRIM25
RIG‑I
RIG‑I is a cytosolic pattern‑recognition receptor that detects viral RNA and activates innate immunity. Its CARD domains become exposed and ubiquitinated by TRIM25, enabling RIG‑I to bind MAVS and trigger interferon production. Through this pathway, RIG‑I converts viral RNA detection into a strong antiviral response.
TRIM25
TRIM25 is a RING finger ubiquitin ligase that activates the antiviral sensor RIG‑I through K63‑linked ubiquitination. Its tripartite motif and PRY/SPRY domain enable precise regulation of innate immune signalling, interferon production and viral restriction. TRIM25 is targeted by multiple viruses, highlighting its importance as a frontline antiviral factor.
RIG‑I
RIG‑I is a cytosolic pattern‑recognition receptor that detects viral RNA and activates innate immunity. Its CARD domains become exposed and ubiquitinated by TRIM25, enabling RIG‑I to bind MAVS and trigger interferon production. Through this pathway, RIG‑I converts viral RNA detection into a strong antiviral response.
TRIM25
TRIM25 is a RING finger ubiquitin ligase that activates the antiviral sensor RIG‑I through K63‑linked ubiquitination. Its tripartite motif and PRY/SPRY domain enable precise regulation of innate immune signalling, interferon production and viral restriction. TRIM25 is targeted by multiple viruses, highlighting its importance as a frontline antiviral factor.