Tag: XIAP
IAP Family
The IAP family consists of intracellular proteins that regulate apoptosis, ubiquitination and immune signalling. Through their BIR domains and RING ligase activity, IAPs control caspase inhibition, NF‑κB activation, inflammasome signalling and tumour cell survival, making them central players in cell biology and cancer research.
XIAP
XIAP is the most potent endogenous inhibitor of caspases and a central regulator of apoptosis and immune signalling. Through its BIR domains and RING ubiquitin ligase activity, XIAP blocks caspase‑3, caspase‑7 and caspase‑9 while modulating NF‑κB pathways, making it a key player in cancer, inflammation and immune disorders.
cIAP2
cIAP2 is a ubiquitin ligase that regulates TNF receptor signalling, non‑canonical NF‑κB activation and NOD2‑mediated immune responses. By controlling RIPK1, RIPK2 and NIK stability, cIAP2 determines whether cells activate survival pathways or transition into apoptosis, making it essential in inflammation and cancer biology.
cIAP1
cIAP1 is a ubiquitin ligase that regulates TNF receptor signalling and determines whether cells activate NF‑κB survival pathways or switch into apoptosis or necroptosis. By controlling RIPK1 ubiquitination and cooperating with TRAF2, cIAP1 plays essential roles in inflammation, immunity and cancer biology.
IAP Family
The IAP family consists of intracellular proteins that regulate apoptosis, ubiquitination and immune signalling. Through their BIR domains and RING ligase activity, IAPs control caspase inhibition, NF‑κB activation, inflammasome signalling and tumour cell survival, making them central players in cell biology and cancer research.
XIAP
XIAP is the most potent endogenous inhibitor of caspases and a central regulator of apoptosis and immune signalling. Through its BIR domains and RING ubiquitin ligase activity, XIAP blocks caspase‑3, caspase‑7 and caspase‑9 while modulating NF‑κB pathways, making it a key player in cancer, inflammation and immune disorders.
cIAP2
cIAP2 is a ubiquitin ligase that regulates TNF receptor signalling, non‑canonical NF‑κB activation and NOD2‑mediated immune responses. By controlling RIPK1, RIPK2 and NIK stability, cIAP2 determines whether cells activate survival pathways or transition into apoptosis, making it essential in inflammation and cancer biology.
cIAP1
cIAP1 is a ubiquitin ligase that regulates TNF receptor signalling and determines whether cells activate NF‑κB survival pathways or switch into apoptosis or necroptosis. By controlling RIPK1 ubiquitination and cooperating with TRAF2, cIAP1 plays essential roles in inflammation, immunity and cancer biology.