The following article describes the zebrafish model to study hypoxia-induced metastasis of mammalian tumor cells.
Lee et al., 2009. Hypoxia-induced pathological angiogenesis mediates tumor cell dissemination, invasion, and metastasis in a zebrafish tumor model. Proc Natl Acad Sci U S A. 106(46), 19485-90. PMID-19887629; Full-Text Links: PNAS, PMC